Lovastatin decreases coenzyme Q levels in rats.

Lovastatin is used for the treatment of hypercholesterolemia. It functions by inhibiting the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (EC 1.1.1.34), that is required for the conversion of 3-hydroxy-3-methylglutaryl-coenzyme A to mevalonic acid. Since biosynthesis of both cholesterol a...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Willis, R A, Folkers, K, Tucker, J L, Ye, C Q, Xia, L J, Tamagawa, H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55073/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2247467/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.22.8928
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