Tsc2 disruption in mesenchymal progenitors results in tumors with vascular anomalies overexpressing Lgals3

Increased mTORC1 signaling from TSC1/TSC2 inactivation is found in cancer and causes tuberous sclerosis complex (TSC). The role of mesenchymal-derived cells in TSC tumorigenesis was investigated through disruption of Tsc2 in craniofacial and limb bud mesenchymal progenitors. Tsc2cKO(Prrx1-cre) mice...

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Bibliographic Details
Published in:eLife
Main Authors: Klover, Peter J, Thangapazham, Rajesh L, Kato, Jiro, Wang, Ji-an, Anderson, Stasia A, Hoffmann, Victoria, Steagall, Wendy K, Li, Shaowei, McCart, Elizabeth, Nathan, Neera, Bernstock, Joshua D, Wilkerson, Matthew D, Dalgard, Clifton L, Moss, Joel, Darling, Thomas N
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Cancer Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505700/
https://ncbi.nlm.nih.gov/pubmed/28695825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.23202
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