Correlation of Higher Antibody Levels to Pneumococcal Proteins with Protection from Pneumococcal Acute Otitis Media but not Protection from Nasopharyngeal Colonization in Young Children

OBJECTIVES: We previously found that nasopharyngeal (NP) colonization by Streptococcus pneumoniae (Spn) elicits mucosal antibody responses to three protein vaccine candidates: pneumococcal histidine triad protein D (PhtD), pneumococcal choline binding protein A (PcpA), and detoxified pneumolysin (Pl...

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Udgivet i:Clin Microbiol Infect
Main Authors: Xu, Qingfu, Casey, Janet R., Almudevar, Anthony, Pichichero, Michael E.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505501/
https://ncbi.nlm.nih.gov/pubmed/28143785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmi.2017.01.011
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