The Human Immunodeficiency Virus 1 ASP RNA promotes viral latency by recruiting the Polycomb Repressor Complex 2 and promoting nucleosome assembly

Various epigenetic marks at the HIV-1 5′LTR suppress proviral expression and promote latency. Cellular antisense transcripts known as long noncoding RNAs (lncRNAs) recruit the polycomb repressor complex 2 (PRC2) to gene promoters, which catalyzes trimethylation of lysine 27 on histone H3 (H3K27me3),...

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Detalhes bibliográficos
Publicado no:Virology
Main Authors: Zapata, Juan C., Campilongo, Federica, Barclay, Robert A., DeMarino, Catherine, Iglesias-Ussel, Maria D., Kashanchi, Fatah, Romerio, Fabio
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5505171/
https://ncbi.nlm.nih.gov/pubmed/28340355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2017.03.002
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