Insulin Receptor Substrate (IRS)-2 negatively regulates alternative macrophage activation and allergic lung inflammation

Insulin Receptor Substrate (IRS)-2 is an adaptor protein that becomes tyrosine phosphorylated in response to IL-4 and IL-13 resulting in activation of the PI-3′ kinase/Akt pathway. While the contribution of IL-4 and IL-13 to allergic lung inflammation has been studied extensively, the functional sig...

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Vydáno v:Sci Signal
Hlavní autoři: Dasgupta, Preeta, Dorsey, Nicolas J., Li, Jiaqi, Qi, Xiulan, Smith, Elizabeth P., Yamaji-Kegan, Kazuyo, Keegan, Achsah D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504879/
https://ncbi.nlm.nih.gov/pubmed/27330190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.aad6724
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