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Local renin-angiotensin system mediates endothelial dilator dysfunction in aging arteries
Aging impairs endothelium-dependent NO-mediated dilatation, which results from increased production of reactive oxygen species (ROS). The local generation of angiotensin II (ANG II) is increased in aging arteries and contributes to inflammatory and fibrotic activity of smooth muscle cells and arteri...
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| Pubblicato in: | Am J Physiol Heart Circ Physiol |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Physiological Society
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5504433/ https://ncbi.nlm.nih.gov/pubmed/27422988 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00422.2016 |
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