Elevated systemic TGF-β impairs aortic vasomotor function through activation of NADPH oxidase-driven superoxide production and leads to hypertension, myocardial remodeling, and increased plaque formation in apoE(−/−) mice

The role of circulating, systemic TGF-β levels in endothelial function is not clear. TGF-β(1) may cause endothelial dysfunction in apolipoprotein E-deficient (apoE(−/−)) mice via stimulation of reactive oxygen species (ROS) production by the NADPH oxidase (NOX) system and aggravate aortic and heart...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Am J Physiol Heart Circ Physiol
Prif Awduron: Buday, Anna, Őrsy, Petra, Godó, Mária, Mózes, Miklós, Kökény, Gábor, Lacza, Zsombor, Koller, Ákos, Ungvári, Zoltán, Gross, Marie-Luise, Benyó, Zoltán, Hamar, Péter
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2010
Pynciau:
Articles
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504387/
https://ncbi.nlm.nih.gov/pubmed/20511416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.01042.2009
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