MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity

A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31(hi)Emcn(hi)), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31(hi)Emcn(hi) vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31(hi)Emcn...

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Publicat a:Nat Commun
Autors principals: Yang, Mi, Li, Chang-Jun, Sun, Xi, Guo, Qi, Xiao, Ye, Su, Tian, Tu, Man-Li, Peng, Hui, Lu, Qiong, Liu, Qing, He, Hong-Bo, Jiang, Tie-Jian, Lei, Min-Xiang, Wan, Mei, Cao, Xu, Luo, Xiang-Hang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2017
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504303/
https://ncbi.nlm.nih.gov/pubmed/28685750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16003
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