MiR-497∼195 cluster regulates angiogenesis during coupling with osteogenesis by maintaining endothelial Notch and HIF-1α activity

A specific bone vessel subtype, strongly positive for CD31 and endomucin (CD31(hi)Emcn(hi)), is identified as coupling angiogenesis and osteogenesis. The abundance of type CD31(hi)Emcn(hi) vessels decrease during ageing. Here we show that expression of the miR-497∼195 cluster is high in CD31(hi)Emcn...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Yang, Mi, Li, Chang-Jun, Sun, Xi, Guo, Qi, Xiao, Ye, Su, Tian, Tu, Man-Li, Peng, Hui, Lu, Qiong, Liu, Qing, He, Hong-Bo, Jiang, Tie-Jian, Lei, Min-Xiang, Wan, Mei, Cao, Xu, Luo, Xiang-Hang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5504303/
https://ncbi.nlm.nih.gov/pubmed/28685750
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms16003
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