Parent-Metabolite Pharmacokinetic Modeling and Pharmacodynamics of Veliparib (ABT-888), a PARP Inhibitor, in Patients with BRCA 1/2 - Mutated Cancer or PARP Sensitive Tumor Types

Veliparib (ABT-888) is a novel oral poly-ADP-ribose polymerase (PARP) inhibitor that is being developed for the treatment of hematologic malignancies and solid tumors. Although the pharmacokinetics of veliparib has been studied in combination with cytotoxic agents, limited information exists regardi...

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Udgivet i:J Clin Pharmacol
Main Authors: Niu, Jing, Scheuerell, Christie, Mehrotra, Shailly, Karan, Sharon, Puhalla, Shannon, Kiesel, Brian F., Ji, Jiuping, Chu, Edward, Gopalakrishnan, Mathangi, Ivaturi, Vijay, Gobburu, Jogarao, Beumer, Jan H.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503785/
https://ncbi.nlm.nih.gov/pubmed/28387939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.892
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