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Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability
Never-in-mitosis A-related kinase 1 (Nek1) has established roles in apoptosis and cell cycle regulation. We show that human Nek1 regulates homologous recombination (HR) by phosphorylating Rad54 at Ser572 in late G2 phase. Nek1 deficiency as well as expression of unphosphorylatable Rad54 (Rad54-S572A...
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| Pubblicato in: | Mol Cell |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5503685/ https://ncbi.nlm.nih.gov/pubmed/27264870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.032 |
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