Nek1 Regulates Rad54 to Orchestrate Homologous Recombination and Replication Fork Stability

Never-in-mitosis A-related kinase 1 (Nek1) has established roles in apoptosis and cell cycle regulation. We show that human Nek1 regulates homologous recombination (HR) by phosphorylating Rad54 at Ser572 in late G2 phase. Nek1 deficiency as well as expression of unphosphorylatable Rad54 (Rad54-S572A...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Mol Cell
Main Authors: Spies, Julian, Waizenegger, Anja, Barton, Olivia, Sürder, Michael, Wright, William D., Heyer, Wolf-Dietrich, Löbrich, Markus
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503685/
https://ncbi.nlm.nih.gov/pubmed/27264870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2016.04.032
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker