HIV-1 Tat inhibits EAAT-2 through AEG-1 upregulation in models of HIV-associated neurocognitive disorder

During HIV-associated neurocognitive disorder (HAND), decreasing in excitatory amino acid transporter 2 (EAAT-2) in astrocyte plasma membranes leads to elevated levels of extracellular glutamate and, in turn, neuronal apoptosis. We used immunohistochemistry, western blot, qRT-PCR, and RNA interferen...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Ye, Xiang, Zhang, Yu, Xu, Qiping, Zheng, Honghua, Wu, Xiaoyan, Qiu, Jinhua, Zhang, Zhou, Wang, Wei, Shao, Yiming, Xing, Hui Qin
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Review
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503662/
https://ncbi.nlm.nih.gov/pubmed/28404980
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16485
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