Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines

Inhibition of the spindle assembly checkpoint kinase TTK causes chromosome mis-segregation and tumor cell death. However, high levels of TTK correlate with chromosomal instability (CIN), which can lead to aneuploidy. We show that treatment of tumor cells with the selective small molecule TTK inhibit...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Libouban, Marion A.A., de Roos, Jeroen A.D.M., Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, de Man, Jos, Tops, Bastiaan, Meijerink, Jules P.P., Storchová, Zuzana, Buijsman, Rogier C., Medema, René H., Zaman, Guido J.R.
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503534/
https://ncbi.nlm.nih.gov/pubmed/28415765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16213
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