Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines

Inhibition of the spindle assembly checkpoint kinase TTK causes chromosome mis-segregation and tumor cell death. However, high levels of TTK correlate with chromosomal instability (CIN), which can lead to aneuploidy. We show that treatment of tumor cells with the selective small molecule TTK inhibit...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Libouban, Marion A.A., de Roos, Jeroen A.D.M., Uitdehaag, Joost C.M., Willemsen-Seegers, Nicole, Mainardi, Sara, Dylus, Jelle, de Man, Jos, Tops, Bastiaan, Meijerink, Jules P.P., Storchová, Zuzana, Buijsman, Rogier C., Medema, René H., Zaman, Guido J.R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2017
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5503534/
https://ncbi.nlm.nih.gov/pubmed/28415765
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16213
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