Alanine-501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness

Resistance of Neisseria gonorrhoeae to expanded-spectrum cephalosporins such as ceftriaxone and cefixime has increased markedly in the past decade. The primary cephalosporin-resistance determinant is a mutated penA gene, which encodes the essential peptidoglycan transpeptidase, penicillin-binding pr...

Descrición completa

Gardado en:
Detalles Bibliográficos
Publicado en:Biochemistry
Main Authors: Tomberg, Joshua, Fedarovich, Alena, Vincent, Leah R., Jerse, Ann E., Unemo, Magnus, Davies, Christopher, Nicholas, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado: 2017
Assuntos:
Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502787/
https://ncbi.nlm.nih.gov/pubmed/28145684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01030
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares