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Bidirectional regulation of Aβ levels by Presenilin 1

Alzheimer’s disease (AD) is characterized by accumulation of the β-amyloid peptide (Aβ), which is generated through sequential proteolysis of the amyloid precursor protein (APP), first by the action of β-secretase, generating the β-C-terminal fragment (βCTF), and then by the Presenilin 1 (PS1) enzym...

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Détails bibliographiques
Publié dans:Proc Natl Acad Sci U S A
Auteurs principaux: Bustos, Victor, Pulina, Maria V., Kelahmetoglu, Yildiz, Sinha, Subhash C., Gorelick, Fred S., Flajolet, Marc, Greengard, Paul
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502639/
https://ncbi.nlm.nih.gov/pubmed/28533411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705235114
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