Recurrent rhinovirus infections in a child with inherited MDA5 deficiency

MDA5 is a cytosolic sensor of double-stranded RNA (ds)RNA including viral byproducts and intermediates. We studied a child with life-threatening, recurrent respiratory tract infections, caused by viruses including human rhinovirus (HRV), influenza virus, and respiratory syncytial virus (RSV). We ide...

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Detalhes bibliográficos
Publicado no:J Exp Med
Main Authors: Lamborn, Ian T., Jing, Huie, Zhang, Yu, Drutman, Scott B., Abbott, Jordan K., Munir, Shirin, Bade, Sangeeta, Murdock, Heardley M., Santos, Celia P., Brock, Linda G., Masutani, Evan, Fordjour, Emmanuel Y., McElwee, Joshua J., Hughes, Jason D., Nichols, Dave P., Belkadi, Aziz, Oler, Andrew J., Happel, Corinne S., Matthews, Helen F., Abel, Laurent, Collins, Peter L., Subbarao, Kanta, Gelfand, Erwin W., Ciancanelli, Michael J., Casanova, Jean-Laurent, Su, Helen C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502429/
https://ncbi.nlm.nih.gov/pubmed/28606988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20161759
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