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The transcription factor Gli3 promotes B cell development in fetal liver through repression of Shh
Before birth, B cells develop in the fetal liver (FL). In this study, we show that Gli3 activity in the FL stroma is required for B cell development. In the Gli3-deficient FL, B cell development was reduced at multiple stages, whereas the Sonic hedgehog (Hh [Shh])–deficient FL showed increased B cel...
Shranjeno v:
| izdano v: | J Exp Med |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
The Rockefeller University Press
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5502423/ https://ncbi.nlm.nih.gov/pubmed/28533268 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20160852 |
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