Anti-Psoriatic Drug Monomethylfumarate Increases Nuclear Factor Erythroid 2-Related Factor 2 Levels and Induces Aquaporin-3 mRNA and Protein Expression

Oxidative stress contributes to inflammatory skin diseases, including psoriasis. Monomethylfumarate (MMF) is an antipsoriatic agent with a poorly understood mechanism of action. In other cell types MMF increases the expression of nuclear factor erythroid-derived 2-like 2 (Nrf2), a transcription fact...

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Bibliographic Details
Published in:J Pharmacol Exp Ther
Main Authors: Helwa, Inas, Choudhary, Vivek, Chen, Xunsheng, Kaddour-Djebbar, Ismail, Bollag, Wendy B.
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2017
Subjects:
Cellular and Molecular
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5502379/
https://ncbi.nlm.nih.gov/pubmed/28515158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.239715
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