Effect of excision repair by diploid human fibroblasts on the kinds and locations of mutations induced by (+/-)-7 beta,8 alpha-dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene in the coding region of the HPRT gene.
(+/-)-7 beta,8 alpha-Dihydroxy-9 alpha,10 alpha-epoxy-7,8,9,10- tetrahydrobenzo[a]pyrene (BPDE) is a direct-acting carcinogen that forms DNA adducts only with purines, predominantly (greater than 95%) with guanine. To investigate the effect of nucleotide excision repair on the kinds and locations (s...
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| Опубликовано в:: | Proc Natl Acad Sci U S A |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
1990
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC55021/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2122466/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.21.8680 |
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