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Lamin B1 levels modulate differentiation into neurons during embryonic corticogenesis

Lamin B1, a key component of the nuclear lamina, plays an important role in brain development. Ablation of endogenous Lamin B1 (Lmnb1) in the mouse strongly impairs embryonic brain development and corticogenesis. However, the mechanisms underlying these neurodevelopmental effects are unknown. Here,...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Sci Rep
Hauptverfasser: Mahajani, Sameehan, Giacomini, Caterina, Marinaro, Federica, De Pietri Tonelli, Davide, Contestabile, Andrea, Gasparini, Laura
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501862/
https://ncbi.nlm.nih.gov/pubmed/28687747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05078-6
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