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PKCα-mediated phosphorylation of LSD1 is required for presynaptic plasticity and hippocampal learning and memory

Lysine-specific demethylase 1 (LSD1) is a histone demethylase that participates in transcriptional repression or activation. Recent studies reported that LSD1 is involved in learning and memory. Although LSD1 phosphorylation by PKCα was implicated in circadian rhythmicity, the importance of LSD1 pho...

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Publicado en:Sci Rep
Main Authors: Lim, Chae-Seok, Nam, Hye Jin, Lee, Jaehyun, Kim, Dongha, Choi, Ja Eun, Kang, SukJae Joshua, Kim, Somi, Kim, Hyopil, Kwak, Chuljung, Shim, Kyu-Won, Kim, Siyong, Ko, Hyoung-Gon, Lee, Ro Un, Jang, Eun-Hae, Yoo, Juyoun, Shim, Jaehoon, Islam, Md Ariful, Lee, Yong-Seok, Lee, Jae-Hyung, Baek, Sung Hee, Kaang, Bong-Kiun
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501860/
https://ncbi.nlm.nih.gov/pubmed/28687800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05239-7
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