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Chronic inflammation triggered by the NLRP3 inflammasome in myeloid cells promotes growth plate dysplasia by mesenchymal cells

Skeletal complications are common features of neonatal-onset multisystem inflammatory disease (NOMID), a disorder caused by NLRP3-activating mutations. NOMID mice in which NLRP3 is activated globally exhibit several characteristics of the human disease, including systemic inflammation and cartilage...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:Sci Rep
Main Authors: Wang, Chun, Xu, Can-Xin, Alippe, Yael, Qu, Chao, Xiao, Jianqiu, Schipani, Ernestina, Civitelli, Roberto, Abu-Amer, Yousef, Mbalaviele, Gabriel
פורמט: Artigo
שפה:Inglês
יצא לאור: Nature Publishing Group UK 2017
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501802/
https://ncbi.nlm.nih.gov/pubmed/28687790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05033-5
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