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Lack of a peroxiredoxin suppresses the lethality of cells devoid of electron donors by channelling electrons to oxidized ribonucleotide reductase

The thioredoxin and glutaredoxin pathways are responsible of recycling several enzymes which undergo intramolecular disulfide bond formation as part of their catalytic cycles such as the peroxide scavengers peroxiredoxins or the enzyme ribonucleotide reductase (RNR). RNR, the rate-limiting enzyme of...

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Detalles Bibliográficos
Publicado en:PLoS Genet
Main Authors: Boronat, Susanna, Domènech, Alba, Carmona, Mercè, García-Santamarina, Sarela, Bañó, M. Carmen, Ayté, José, Hidalgo, Elena
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501661/
https://ncbi.nlm.nih.gov/pubmed/28640807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006858
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