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Dual TCRα expression poses an autoimmune hazard by limiting T(reg) cell generation

Despite accounting for 10–30% of the T cell population in mice and humans, the role of dual TCR-expressing T cells in immunity remains poorly understood. It has been hypothesized that dual TCR T cells pose an “autoimmune hazard” by allowing self-reactive TCRs to escape thymic selection. We revisited...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Schuldt, Nathaniel J., Auger, Jennifer L., Spanier, Justin A., Martinov, Tijana, Breed, Elise R., Fife, Brian T., Hogquist, Kristin A., Binstadt, Bryce A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501482/
https://ncbi.nlm.nih.gov/pubmed/28539428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700406
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