PAM50 gene signatures and breast cancer prognosis with adjuvant anthracycline- and taxane-based chemotherapy: correlative analysis of C9741 (Alliance)

PAM50 intrinsic breast cancer subtypes are prognostic independent of standard clinicopathologic factors. CALGB 9741 demonstrated improved recurrence-free (RFS) and overall survival (OS) with 2-weekly dose-dense (DD) versus 3-weekly therapy. A significant interaction between intrinsic subtypes and DD...

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Udgivet i:NPJ Breast Cancer
Main Authors: Liu, Minetta C, Pitcher, Brandelyn N, Mardis, Elaine R, Davies, Sherri R, Friedman, Paula N, Snider, Jacqueline E, Vickery, Tammi L, Reed, Jerry P, DeSchryver, Katherine, Singh, Baljit, Gradishar, William J, Perez, Edith A, Martino, Silvana, Citron, Marc L, Norton, Larry, Winer, Eric P, Hudis, Clifford A, Carey, Lisa A, Bernard, Philip S, Nielsen, Torsten O, Perou, Charles M, Ellis, Matthew J, Barry, William T
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501351/
https://ncbi.nlm.nih.gov/pubmed/28691057
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npjbcancer.2015.23
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