Development and verification of the PAM50-based Prosigna breast cancer gene signature assay

BACKGROUND: The four intrinsic subtypes of breast cancer, defined by differential expression of 50 genes (PAM50), have been shown to be predictive of risk of recurrence and benefit of hormonal therapy and chemotherapy. Here we describe the development of Prosigna™, a PAM50-based subtype classifier a...

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Bibliografische gegevens
Gepubliceerd in:BMC Med Genomics
Hoofdauteurs: Wallden, Brett, Storhoff, James, Nielsen, Torsten, Dowidar, Naeem, Schaper, Carl, Ferree, Sean, Liu, Shuzhen, Leung, Samuel, Geiss, Gary, Snider, Jacqueline, Vickery, Tammi, Davies, Sherri R., Mardis, Elaine R., Gnant, Michael, Sestak, Ivana, Ellis, Matthew J., Perou, Charles M., Bernard, Philip S., Parker, Joel S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2015
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546262/
https://ncbi.nlm.nih.gov/pubmed/26297356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12920-015-0129-6
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