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CHEMOGENETIC INHIBITION OF PAIN NEURONS IN A MOUSE MODEL OF OSTEOARTHRITIS

OBJECTIVE: The purpose of this study was to determine the ability of drugs that activate inhibitory G-protein coupled receptors (GPCRs) expressed in peripheral Na(V)1.8-positive sensory neurons to control osteoarthritis associated pain. Therefore, we used Designer Receptors Exclusively Activated by...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Miller, Rachel E., Ishihara, Shingo, Bhattacharyya, Bula, Delaney, Ada, Menichella, Daniela M., Miller, Richard J., Malfait, Anne-Marie
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501168/
https://ncbi.nlm.nih.gov/pubmed/28380690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40118
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