CHEMOGENETIC INHIBITION OF PAIN NEURONS IN A MOUSE MODEL OF OSTEOARTHRITIS

OBJECTIVE: The purpose of this study was to determine the ability of drugs that activate inhibitory G-protein coupled receptors (GPCRs) expressed in peripheral Na(V)1.8-positive sensory neurons to control osteoarthritis associated pain. Therefore, we used Designer Receptors Exclusively Activated by...

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Vydáno v:Arthritis Rheumatol
Hlavní autoři: Miller, Rachel E., Ishihara, Shingo, Bhattacharyya, Bula, Delaney, Ada, Menichella, Daniela M., Miller, Richard J., Malfait, Anne-Marie
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5501168/
https://ncbi.nlm.nih.gov/pubmed/28380690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40118
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