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An inhibitor of ubiquitin conjugation and aggresome formation
Proteasome inhibitors have revolutionized the treatment of multiple myeloma, and validated the therapeutic potential of the ubiquitin proteasome system (UPS). It is believed that in part, proteasome inhibitors elicit their therapeutic effect by inhibiting the degradation of misfolded proteins, which...
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| Publicado en: | Chem Sci |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Royal Society of Chemistry
2015
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500945/ https://ncbi.nlm.nih.gov/pubmed/28717502 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc01351h |
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