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Protein ubiquitination and formation of polyubiquitin chains without ATP, E1 and E2 enzymes
Studying protein ubiquitination is difficult due to the complexity of the E1–E2–E3 ubiquitination cascade. Here we report the discovery that C-terminal ubiquitin thioesters can undergo direct transthiolation with the catalytic cysteine of the model HECT E3 ubiquitin ligase Rsp5 to form a catalytical...
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| Veröffentlicht in: | Chem Sci |
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| Hauptverfasser: | , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Royal Society of Chemistry
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5485889/ https://ncbi.nlm.nih.gov/pubmed/28706640 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc02340d |
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