The m(6)A pathway facilitates sex determination in Drosophila

The conserved modification N(6)-methyladenosine (m(6)A) modulates mRNA processing and activity. Here, we establish the Drosophila system to study the m(6)A pathway. We first apply miCLIP to map m(6)A across embryogenesis, characterize its m(6)A ‘writer’ complex, validate its YTH ‘readers’ CG6422 and...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Kan, Lijuan, Grozhik, Anya V., Vedanayagam, Jeffrey, Patil, Deepak P., Pang, Nan, Lim, Kok-Seong, Huang, Yi-Chun, Joseph, Brian, Lin, Ching-Jung, Despic, Vladimir, Guo, Jian, Yan, Dong, Kondo, Shu, Deng, Wu-Min, Dedon, Peter C., Jaffrey, Samie R., Lai, Eric C.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5500889/
https://ncbi.nlm.nih.gov/pubmed/28675155
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15737
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