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The role of topoisomerases and RNA transcription in the action of the antitumour benzonaphthyridine derivative SN 28049
PURPOSE: SN 28049 (N-[2-(dimethylamino)ethyl]-2,6-dimethyl-1-oxo-1,2-dihydrobenzo[b]-1,6-naphthyridine-4-carboxamide) is a DNA intercalating drug that binds selectively to GC-rich DNA and shows curative activity against the Colon 38 adenocarcinoma in mice. We wished to investigate the roles of topoi...
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| Publicado no: | Cancer Chemother Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5500182/ https://ncbi.nlm.nih.gov/pubmed/18175117 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-007-0660-z |
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