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Mechanism of the Association Pathways for a Pair of Fast and Slow Binding Ligands of HIV‑1 Protease

Equilibrium constants, together with kinetic rate constants of binding, are key factors in the efficacy and safety of drug compounds, informing drug design. However, the association pathways of protein–ligand binding, which contribute to their kinetic behaviors, are little understood. In this work,...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biochemistry
Prif Awduron: Huang, Yu-ming M., Raymundo, Mark Anthony V., Chen, Wei, Chang, Chia-en A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2017
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499997/
https://ncbi.nlm.nih.gov/pubmed/28060481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01112
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