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Mechanism of the Association Pathways for a Pair of Fast and Slow Binding Ligands of HIV‑1 Protease
Equilibrium constants, together with kinetic rate constants of binding, are key factors in the efficacy and safety of drug compounds, informing drug design. However, the association pathways of protein–ligand binding, which contribute to their kinetic behaviors, are little understood. In this work,...
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| Publicado no: | Biochemistry |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499997/ https://ncbi.nlm.nih.gov/pubmed/28060481 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01112 |
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