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Chronic lithium treatment elicits its antimanic effects via BDNF-TrkB dependent synaptic downscaling
Lithium is widely used as a treatment for Bipolar Disorder although the molecular mechanisms that underlie its therapeutic effects are under debate. In this study, we show brain-derived neurotrophic factor (BDNF) is required for the antimanic-like effects of lithium but not the antidepressant-like e...
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| Yayımlandı: | eLife |
|---|---|
| Asıl Yazarlar: | , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
eLife Sciences Publications, Ltd
2017
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499943/ https://ncbi.nlm.nih.gov/pubmed/28621662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25480 |
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