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Modeling bias and variation in the stochastic processes of small RNA sequencing
The use of RNA-seq as the preferred method for the discovery and validation of small RNA biomarkers has been hindered by high quantitative variability and biased sequence counts. In this paper we develop a statistical model for sequence counts that accounts for ligase bias and stochastic variation i...
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| Publicado no: | Nucleic Acids Res |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5499834/ https://ncbi.nlm.nih.gov/pubmed/28369495 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx199 |
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