BRG1 interacts with SOX10 to establish the melanocyte lineage and to promote differentiation

Mutations in SOX10 cause neurocristopathies which display varying degrees of hypopigmentation. Using a sensitized mutagenesis screen, we identified Smarca4 as a modifier gene that exacerbates the phenotypic severity of Sox10 haplo-insufficient mice. Conditional deletion of Smarca4 in SOX10 expressin...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Marathe, Himangi G., Watkins-Chow, Dawn E., Weider, Matthias, Hoffmann, Alana, Mehta, Gaurav, Trivedi, Archit, Aras, Shweta, Basuroy, Tupa, Mehrotra, Aanchal, Bennett, Dorothy C., Wegner, Michael, Pavan, William J., de la Serna, Ivana L.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Gene regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499657/
https://ncbi.nlm.nih.gov/pubmed/28431046
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx259
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