New somatic BRAF splicing mutation in Langerhans cell histiocytosis

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia with constitutive activation of the MAPKinase RAS-RAF-MEK-ERK cell signaling pathway. We analyzed 9 LCH cases without BRAF (V600) and MAP2K1 mutations by whole exome sequencing. We identified a new somatic BRAF splicing mutatio...

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Dades bibliogràfiques
Publicat a:Mol Cancer
Autors principals: Héritier, Sébastien, Hélias-Rodzewicz, Zofia, Chakraborty, Rikhia, Sengal, Amel G., Bellanné-Chantelot, Christine, Thomas, Caroline, Moreau, Anne, Fraitag, Sylvie, Allen, Carl E., Donadieu, Jean, Emile, Jean-François
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2017
Matèries:
Letter to the Editor
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498996/
https://ncbi.nlm.nih.gov/pubmed/28679432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0690-z
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