Association of DNA Mismatch Repair and Mutations in BRAF and KRAS with Survival after Recurrence in Stage III Colon Cancers from Phase III Adjuvant Chemotherapy Trials

IMPORTANCE: The association of biomarkers with patient survival after recurrence (SAR) is poorly understood, yet may guide management and treatment. OBJECTIVE: To determine the association of DNA mismatch repair (MMR) status and somatic mutations in BRAF(V600E) or KRAS (exon 2) in the primary tumor...

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Vydáno v:JAMA Oncol
Hlavní autoři: Sinicrope, Frank A., Shi, Qian, Allegra, Carmen J., Smyrk, Thomas C., Thibodeau, Stephen N., Goldberg, Richard M., Meyers, Jeffrey P., Pogue-Geile, Kay L., Yothers, Greg, Sargent, Daniel J., Alberts, Steven R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498991/
https://ncbi.nlm.nih.gov/pubmed/28006055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaoncol.2016.5469
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