Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity

Inhibition of Notch signaling via systemic drug administration triggers conversion of white adipocytes into beige adipocytes (browning) and reduces adiposity. However, translation of this discovery into clinical practice is challenged by potential off-target side effects and lack of control over the...

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Dettagli Bibliografici
Pubblicato in:Mol Ther
Autori principali: Jiang, Chunhui, Cano-Vega, Mario Alberto, Yue, Feng, Kuang, Liangju, Narayanan, Naagarajan, Uzunalli, Gozde, Merkel, Madeline P., Kuang, Shihuan, Deng, Meng
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Gene & Cell Therapy 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498918/
https://ncbi.nlm.nih.gov/pubmed/28624262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.020
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