Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity

Inhibition of Notch signaling via systemic drug administration triggers conversion of white adipocytes into beige adipocytes (browning) and reduces adiposity. However, translation of this discovery into clinical practice is challenged by potential off-target side effects and lack of control over the...

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Veröffentlicht in:Mol Ther
Hauptverfasser: Jiang, Chunhui, Cano-Vega, Mario Alberto, Yue, Feng, Kuang, Liangju, Narayanan, Naagarajan, Uzunalli, Gozde, Merkel, Madeline P., Kuang, Shihuan, Deng, Meng
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Gene & Cell Therapy 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498918/
https://ncbi.nlm.nih.gov/pubmed/28624262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.020
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