Dibenzazepine-Loaded Nanoparticles Induce Local Browning of White Adipose Tissue to Counteract Obesity

Inhibition of Notch signaling via systemic drug administration triggers conversion of white adipocytes into beige adipocytes (browning) and reduces adiposity. However, translation of this discovery into clinical practice is challenged by potential off-target side effects and lack of control over the...

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Publicado en:Mol Ther
Main Authors: Jiang, Chunhui, Cano-Vega, Mario Alberto, Yue, Feng, Kuang, Liangju, Narayanan, Naagarajan, Uzunalli, Gozde, Merkel, Madeline P., Kuang, Shihuan, Deng, Meng
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2017
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498918/
https://ncbi.nlm.nih.gov/pubmed/28624262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2017.05.020
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