Aging is protective against pressure overload cardiomyopathy via adaptive extracellular matrix remodeling

When challenged by hemodynamic stress, aging hearts respond differently to young hearts. Preclinical models of heart disease should take into account the effects of age. However, in the transverse aortic constriction (TAC) model of pressure-overload cardiomyopathy, the larger aorta of aging mice has...

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Veröffentlicht in:Am J Cardiovasc Dis
Hauptverfasser: Geng, Xiaoyong, Hwang, Joy, Ye, Jianqin, Shih, Henry, Coulter, Brianna, Naudin, Crystal, Jun, Kristine, Sievers, Richard, Yeghiazarians, Yerem, Lee, Randall J, Boyle, Andrew J
Format: Artigo
Sprache:Inglês
Veröffentlicht: e-Century Publishing Corporation 2017
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498818/
https://ncbi.nlm.nih.gov/pubmed/28695053
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