Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

Overcoming adverse effects and selectively delivering drug to target cells are two major challenges in the treatment of ulcerative colitis (UC). Lysine-proline-valine (KPV), a naturally occurring tripeptide, has been shown to attenuate the inflammatory responses of colonic cells. Here, we loaded KPV...

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Bibliographic Details
Published in:Mol Ther
Main Authors: Xiao, Bo, Xu, Zhigang, Viennois, Emilie, Zhang, Yuchen, Zhang, Zhan, Zhang, Mingzhen, Han, Moon Kwon, Kang, Yuejun, Merlin, Didier
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2017
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498804/
https://ncbi.nlm.nih.gov/pubmed/28143741
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2016.11.020
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