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Linking functions: an additional role for an intrinsically disordered linker domain in the transcriptional coactivator CBP

The multi-domain transcriptional coactivators CBP/p300 integrate a multitude of signaling inputs, interacting with more than 400 proteins via one or more of their globular domains. While CBP/p300 function is typically considered in terms of these structured domains, about half of the protein consist...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Contreras-Martos, Sara, Piai, Alessandro, Kosol, Simone, Varadi, Mihaly, Bekesi, Angela, Lebrun, Pierre, Volkov, Alexander N., Gevaert, Kris, Pierattelli, Roberta, Felli, Isabella C., Tompa, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498717/
https://ncbi.nlm.nih.gov/pubmed/28680062
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-04611-x
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