Just a Flexible Linker? The Structural and Dynamic Properties of CBP-ID4 Revealed by NMR Spectroscopy

Here, we present a structural and dynamic description of CBP-ID4 at atomic resolution. ID4 is the fourth intrinsically disordered linker of CREB-binding protein (CBP). In spite of the largely disordered nature of CBP-ID4, NMR chemical shifts and relaxation measurements show a significant degree of α...

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Bibliografiske detaljer
Udgivet i:Biophys J
Main Authors: Piai, Alessandro, Calçada, Eduardo O., Tarenzi, Thomas, Grande, Alessandro del, Varadi, Mihaly, Tompa, Peter, Felli, Isabella C., Pierattelli, Roberta
Format: Artigo
Sprog:Inglês
Udgivet: The Biophysical Society 2016
Fag:
Proteins
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4724632/
https://ncbi.nlm.nih.gov/pubmed/26789760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.11.3516
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