Cardiac Subtype-Specific Modeling of K(v)1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells

The ultrarapid delayed rectifier K(+) current (I(Kur)), mediated by K(v)1.5 channels, constitutes a key component of the atrial action potential. Functional mutations in the underlying KCNA5 gene have been shown to cause hereditary forms of atrial fibrillation (AF). Here, we combine targeted genetic...

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Detalles Bibliográficos
Publicado en:Front Physiol
Main Authors: Marczenke, Maike, Piccini, Ilaria, Mengarelli, Isabella, Fell, Jakob, Röpke, Albrecht, Seebohm, Guiscard, Verkerk, Arie O., Greber, Boris
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2017
Assuntos:
Physiology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498524/
https://ncbi.nlm.nih.gov/pubmed/28729840
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2017.00469
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