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Selective Effects of PD-1 on Akt and Ras Pathways Regulate Molecular Components of the Cell Cycle and Inhibit T Cell Proliferation

The receptor programmed death 1 (PD-1) inhibits T cell proliferation and plays a critical role in suppressing self-reactive T cells, and it also compromises antiviral and antitumor responses. To determine how PD-1 signaling inhibits T cell proliferation, we used human CD4(+) T cells to examine the e...

詳細記述

保存先:
書誌詳細
出版年:Sci Signal
主要な著者: Patsoukis, Nikolaos, Brown, Julia, Petkova, Victoria, Liu, Fang, Li, Lequn, Boussiotis, Vassiliki A.
フォーマット: Artigo
言語:Inglês
出版事項: 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498435/
https://ncbi.nlm.nih.gov/pubmed/22740686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2002796
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