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Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP

Alzheimer’s disease (AD) is an age-related neurodegenerative disorder characterized by aggregation of toxic forms of amyloid β peptide (Aβ). Treatment strategies have largely been focused on inhibiting the enzymes (β- and γ-secretases) that liberate Aβ from the amyloid precursor protein (APP). While...

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Detalhes bibliográficos
Publicado no:J Neurochem
Main Authors: Nigam, Saket M., Xu, Shaohua, Kritikou, Joanna S., Marosi, Krisztina, Brodin, Lennart, Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498234/
https://ncbi.nlm.nih.gov/pubmed/28382744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jnc.14034
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