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Design, synthesis, and biological characterization of novel PEG-linked dimeric modulators for CXCR4

CXCR4 dimerization has been widely demonstrated both biologically and structurally. This paper mainly focused on the development of structure-based dimeric ligands that target SDF-1α-CXCR4 interaction and signaling. This study presents the design and synthesis of a series of [PEG]n ([-CH(2)-CH(2)-O-...

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Detalhes bibliográficos
Publicado no:Bioorg Med Chem
Main Authors: Yang, Yilei, Gao, Mei, Zhang, Qinghao, Yang, Xiaohong, Huang, Ziwei, An, Jing
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498155/
https://ncbi.nlm.nih.gov/pubmed/27658790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.08.062
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