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Genome-wide mapping of autonomous promoter activity in human cells

Previous methods to systematically characterize sequence-intrinsic activity of promoters have been limited by relatively low throughput and the length of sequences that could be tested. Here we present Survey of Regulatory Elements (SuRE), a method to assay more than 10(8) DNA fragments, each 0.2–2k...

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Publicat a:Nat Biotechnol
Autors principals: van Arensbergen, Joris, FitzPatrick, Vincent D., de Haas, Marcel, Pagie, Ludo, Sluimer, Jasper, Bussemaker, Harmen J., van Steensel, Bas
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5498152/
https://ncbi.nlm.nih.gov/pubmed/28024146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nbt.3754
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