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Activation of Dun1 in response to nuclear DNA instability accounts for the increase in mitochondrial point mutations in Rad27/FEN1 deficient S. cerevisiae

Rad27/FEN1 nuclease that plays important roles in the maintenance of DNA stability in the nucleus has recently been shown to reside in mitochondria. Accordingly, it has been established that Rad27 deficiency causes increased mutagenesis, but decreased microsatellite instability and homologous recomb...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:PLoS One
Päätekijät: Kaniak-Golik, Aneta, Kuberska, Renata, Dzierzbicki, Piotr, Sledziewska-Gojska, Ewa
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Public Library of Science 2017
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497989/
https://ncbi.nlm.nih.gov/pubmed/28678842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0180153
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